NOTCH1 and acute lymphoblastic leukemia: This mutation leads to ligand‐independent activation of Notch1, promoting uncontrolled proliferation and cell survival.[7, 8, 9] Notch1 plays a critical role in hematopoietic cell fate determination, which explains the strong selection pressure for oncogenic Notch mutations in T‐ALL.[10] Due to its high mutation frequency, Notch1 is an attractive therapeutic target, spurring the development of small‐molecule inhibitors aimed at the Notch1 signaling pathway.