Previous studies have shown that UBC9 plays a part in macrophage polarization.[13, 43] Our earlier work demonstrated the essential function of UBC9 in facilitating IL‐4‐induced M2 polarization of macrophages.[13] In prostate cancer, UBC9 deficiency has been linked to enhanced macrophage activation and antigen presentation.[44] Here, we observed that UBC9 deficiency decreases angiogenic factor VEGFA in hypoxic macrophages, adding a new dimension of macrophage plasticity. This evidence concerns the gene IL4 and Familial prostate cancer.