≈70% of MFDM cases result from de novo EFTUD2 mutations, as documented in the EFTUD2 Mutation Database http://databases.lovd.nl/shared/genes/EFTUD2).[26] A meta‐analysis of clinically reported MFDM‐associated mutations (Figure S1A, Supporting Information) revealed strong evolutionary conservation across mammalian species, including Homo sapiens, Pan troglodytes, and Mus musculus (Figure S1B, Supporting Information), indicating that these variants localize to critical functional domains. The gene discussed is EFTUD2; the disease is mandibulofacial dysostosis-microcephaly syndrome.