ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2), collagen type xii alpha 1 chain (COL12A1), and thrombospondin 2 (THBS2), which contribute to extracellular matrix (ECM) formation, are regulated by m6A modification of mRNA, and knockdown of FTO reduces their mRNA levels and m6A modification levels, suppressing migration and invasion of pancreatic cancer cells [65]. This evidence concerns the gene THBS2 and familial pancreatic carcinoma.