Tissue factor pathway inhibitor 2 (TFPI‐2) mRNA is m6A‐modified and stabilized by binding to YTHDF1, which upregulates TFPI‐2 expression and suppresses tumor growth, migration, and invasion, but removal of m6A‐modification by FTO reduces TFPI‐2 expression and promotes cancer progression [63]. The gene discussed is FTO; the disease is cancer.