Concentrations of activin‐A, Fas, IL‐6, TNFR1, and TNFR2 were higher in both obese and T2DM participants than in lean participants, and concentrations of GDF‐15, GROa, IL‐8, and TNFa were also higher in participants with T2DM compared to lean controls. This evidence concerns the gene TNF and type 2 diabetes mellitus.