In the literature, GLP1R‐agonists have had more variable effects on cellular senescence—liraglutide induced cellular senescence and had an anti‐proliferative effect in hepatocellular carcinoma cells (Krause et al. 2017), while exendin‐4 downregulated the expression of p16 and p21Cip1 in rat osteoblasts (Zhang et al. 2019). The gene discussed is CDKN2A; the disease is hepatocellular carcinoma.