Regarding human transcripts, features associated to HSIL included the pro-tumor genes MYC (Imp. = [5.5–42.0]), ERBB2 (Imp. = [25.6–83.4]), WNT1 (Imp. = [2.4–23.4]), HRAS (Imp. = 3.4 in S + uS + H) and TERT (Imp. = 62.7 in uS + H), the proliferation marker PCNA (Imp. = [5.6–24.3]), NOTCH1 (Imp. = [35.5–71.0]) which is involved in cell fate determination and differentiation, but also the tumor suppressor genes CDKN2A (Imp. = [26.9–33.9]), TP53 (Imp. = [6.8–9.8]), RB1 (Imp. = [0.9–8.9]) (Fig. 4). Here, NOTCH1 is linked to neoplasm.