ERN1 and metabolic dysfunction-associated steatohepatitis: In nonalcoholic steatohepatitis, mitotic protein 2 (Mfn2) promotes ferroptosis by interacting with inositol demand enzyme (IRE1α) to promote the production of 5-HETE and ferroptosis and hepatitis is significantly alleviated by reducing the content of 5-HETE [65].