NCAM1 and neuroblastoma: To identify the key driver of neuroblastoma differentiation within SLIT-ROBO signaling, 9 candidate genes (NCAM1, NRCAM, VSTM2L, SLIT2, SLIT3, NECTIN1, ALCAM, NRP1, and NRP2) were selected from the 57 upregulated secretome genes associated with axon guidance term (Fig. 2I, J).