To identify the key driver of neuroblastoma differentiation within SLIT-ROBO signaling, 9 candidate genes (NCAM1, NRCAM, VSTM2L, SLIT2, SLIT3, NECTIN1, ALCAM, NRP1, and NRP2) were selected from the 57 upregulated secretome genes associated with axon guidance term (Fig. 2I, J). This evidence concerns the gene SLIT2 and neuroblastoma.