Additionally, circSLC22A3 formed a protein-RNA complex with IGF2BP1 and facilitated degradation of acyl-CoA Synthetase Bubblegum Family Member 1 (ACSBG1) mRNA through recognition of m6A modification, resulting in inhibition of migration and invasion in ESCC. Here, IGF2BP1 is linked to esophageal squamous cell carcinoma.