In addition, IGF2BP1 was generally highly expressed in ESCC cells and tumor tissues (Fig. S5A and S5B), while the immunohistochemistry results demonstrated that, in patients with ESCC, the expression level of IGF2BP1 was significantly elevated in patients with poorly and moderately differentiated ESCC compared with that found in patients with highly differentiated ESCC. Here, IGF2BP1 is linked to esophageal squamous cell carcinoma.