For instance, in non-small cell lung cancer, circNDUFB2 acted as a scaffold to enhance the interaction between TRIM25 and IGF2BPs, and the resulting ternary complex formed by TRIM25, circNDUFB2 and IGF2BPs promoted the ubiquitination and degradation of IGF2BPs while also stimulating immune response mechanisms that inhibited tumor growth and metastasis [35]. The gene discussed is TRIM25; the disease is non-small cell lung carcinoma.