Acting as a tumor suppressor, circSLC22A3 exerted a negative regulation on the metastatic potential of ESCC through two mechanisms: Firstly, as a sponge for miR-19b-3p, it enhances the expression of TRAK2; secondly, by binding to IGF2BP1, it modulates the stability of ACSBG1 mRNA in a manner dependent on the recognition of m6A modification, thereby downregulating ACSBG1 expression (Fig. 8). Here, TRAK2 is linked to neoplasm.