For instance, in non-small cell lung cancer, circNDUFB2 acted as a scaffold to enhance the interaction between TRIM25 and IGF2BPs, and the resulting ternary complex formed by TRIM25, circNDUFB2 and IGF2BPs promoted the ubiquitination and degradation of IGF2BPs while also stimulating immune response mechanisms that inhibited tumor growth and metastasis [35]. This evidence concerns the gene TRIM25 and neoplasm.