OSBPL8 and steatosis: Furthermore, Osbpl8 clearly reduced triglyceride accumulation, increased alanine transaminase (ALT) and aspartate transaminase (AST) levels (Fig. 4B-C), accelerated ATP generation (Fig. 4D), and attenuated steatosis, inflammation and oxidative stress (Fig. 4E-F & Fig. S4-S5).