OSBPL8 and fatty liver disease: H&E and Oil Red O staining revealed that, compared with mice in the control group, Osbpl8-knockdown mice exhibited severe hepatic steatosis, hepatocyte ballooning, and neutrophil infiltration, while the administration of Osbpl8-enriched M2-BMDM-EVs significantly improved hepatic steatosis and inflammation (Fig. 6 & S7).