Defects in IL-36R signaling have been described in generalized pustular psoriasis (GPP), where heterozygous, compound heterozygous and homozygous mutations in the gene encoding IL-36RA (IL36RN) lead to the rare deficiency of interleukin thirty-six–receptor antagonist (DITRA) syndrome (Marrakchi et al, 2011; Tauber et al, 2016). The gene discussed is IL36RN; the disease is generalized pustular psoriasis.