AFP and hepatocellular carcinoma: However, no significant correlation was found between baseline AFP levels and the objective response rate (ORR) in ICI-treated HCC patients (8 studies, 1043 individuals; odds ratio (OR): 0.963, 95% CI 0.710–1.306, p = 0.933; I2 = 10.0%, p = 0.353) [22].