A patient-derived mutation truncating the C-terminal HhH domain (p.Arg1931∗; rs144567652) associated with cancer predisposition (Peterlongo et al, 2015) and infertility (Kasak et al, 2018) showed similar defects, and is consistent with previous observations that both the C-terminal region and FAAP24 are essential for FANCM function (Coulthard et al, 2013; Yang et al, 2013). The gene discussed is FANCM; the disease is cancer.