THBS4 and ischemic cardiomyopathy: Bulk RNA-seq data from the GSE116250 cohort revealed significant overlap between ischemic cardiomyopathy (ICM)-associated differentially expressed genes (DEGs) and FB3-specific markers (THBS4, NTM, NRK, COL14 A1 upregulated; MGST1 downregulated) (Figure S5A, C, Supplementary Table 3).