ACTA1 and malignant colon neoplasm: FGFR4 expression was significantly positively correlated with that of CXCL10 (Pearson’s R = 0.32; P < 0.001) and CAF markers, including α-SMA (Pearson’s R = 0.43; P < 0.0001), PDGFR-β (Pearson’s R = 0.46; P < 0.0001), and FAP (Pearson’s R = 0.32; P < 0.001) in colon cancer samples (Fig. 6B, and Fig. S4a, b).