These observations strongly support an association between FGFR4, CXCL10, and CAF marker expression in clinical colon cancer samples and show that FGFR4 is involved in CAF differentiation/activation within the colon cancer TME, emphasizing the clinical relevance of the identified FGFR4-CXCL10-CAF regulatory axis. Here, FGFR4 is linked to colonic neoplasm.