To the best of our knowledge, this is the first report to reveal the interplay between FGFR4 in colon cancer cells and the CXCL10/CXCR3 axis in CAFs, demonstrating the efficacy of dual FGFR4 and CXCR3 inhibition against tumor growth via CAF suppression. Here, FGFR4 is linked to neoplasm.