To the best of our knowledge, this is the first report to reveal the interplay between FGFR4 in colon cancer cells and the CXCL10/CXCR3 axis in CAFs, demonstrating the efficacy of dual FGFR4 and CXCR3 inhibition against tumor growth via CAF suppression. This evidence concerns the gene CXCL10 and malignant colon neoplasm.