Regarding anatomical subsites, two genes were exclusively associated with colon cancer risk (AAMP and ARPC2), three genes with both colon and proximal colon cancer risk (EPM2AIP1, MLH1 and RP11-129K12.1), one with distal colon cancer risk (ABCC2), one with proximal colon cancer risk (LRRFIP2) and three with rectal cancer (COLCA1, LAMC1 and GPATCH1) risk. Here, ARPC2 is linked to colonic neoplasm.