Regarding anatomical subsites, two genes were exclusively associated with colon cancer risk (AAMP and ARPC2), three genes with both colon and proximal colon cancer risk (EPM2AIP1, MLH1 and RP11-129K12.1), one with distal colon cancer risk (ABCC2), one with proximal colon cancer risk (LRRFIP2) and three with rectal cancer (COLCA1, LAMC1 and GPATCH1) risk. The gene discussed is COLCA1; the disease is rectal cancer.