SNCA and Atrophy: It is important to keep in mind that our model was built on atrophy and not actual pathology, and that although preliminary evidence has shown that atrophy in synucleinopathies can be recreated in silico as a spread of alpha-synuclein misfolded proteins,5 several other proteins and co-pathologies may also be at play in iRBD-associated neurodegeneration.