Conversely, none of the 16 MS or 15 SLE or 9 PsA patients (figure 1E), or 22 healthy controls (figure 1F) exhibited this filamentous staining pattern, indicating that NF-M immunoreactivity assessed with indirect immunolabelling of mouse brain sections may serve as both a sensitive and specific marker for BD. This evidence concerns the gene NEFM and systemic lupus erythematosus.