The fact that rAra h 6 was capable of triggering PNA serum and Ara h 2 affinity-purified IgE-mediated PCA reaction also indirectly suggested that the repeated DPYSPS sequence was not important in triggering peanut allergic reaction because these motifs of Ara h 2 were deleted, and therefore did not exist, in Ara h 6. Here, IGHE is linked to allergic disease.