EGFR and non-small cell lung carcinoma: As shown in Figure S4, A–C, while curcumin or nebivolol alone inhibited PC-9EGFR-T790M/C797S-driven NSCLC tumor growth, in consistent with previous reports that nebivolol can inhibit β1 adrenergic receptors or EGFR to suppress tumor growth (30, 33), the combination of curcumin and nebivolol exhibited significantly better inhibitory effects.