TP53 and Lynch syndrome: Finally, two additional and related limitations of our study were our limited evidence for GC causality, as association testing resulted in nominally significant values for a handful of genes (ATM, BRCA2, MLH1, RAD51D, and TP53; see Supplementary Table S8), and the possibility that these variants may be associated with other cancer types that are more common in HBOC or Lynch Syndrome.