Finally, two additional and related limitations of our study were our limited evidence for GC causality, as association testing resulted in nominally significant values for a handful of genes (ATM, BRCA2, MLH1, RAD51D, and TP53; see Supplementary Table S8), and the possibility that these variants may be associated with other cancer types that are more common in HBOC or Lynch Syndrome. Here, TP53 is linked to cancer.