We and others have identified families and patients with GC harbouring germline variants in multi-organ cancer genes such as ATM, BRCA1, BRCA2, and PALB2, suggesting that these genes may be involved in GC predisposition.13, 14, 15, 16, 17, 18 As genes involved in homologous recombination (HR) repair, these findings are of dual importance: genetic risk information can be utilised in genetic counselling, surveillance, and risk reduction measures, while also contributing to the development of novel GC treatments. The gene discussed is PALB2; the disease is gastric cancer.