CDH1 and gastric cancer: The most well-known GC inherited form is Hereditary Diffuse Gastric Cancer (HDGC), a syndrome associated with the presence of diffuse-type histology gastric carcinomas caused by germline variants in CDH1 or CTNNA1. 1,6 Nonetheless, pathogenic/likely pathogenic (P/LP) variants in these two genes only account for ∼42% of HDGC families.7