We employ the Eμ-Myc mouse model [19] and the P493-6 cell line [20] to model the cellular response to supraphysiological Myc overexpression in B lymphocytes, we use splenic murine (male, 6w) primary B lymphocytes activated with lipopolysaccharides (LPS) as a comparator to induce physiologically relevant enhanced levels of Myc expression, and we utilize the Burkitt's lymphoma-derived CA46 and DG-75 cell lines as models of bona fide Myc-dependent cancer cells. This evidence concerns the gene MYC and cancer.