PRPS1 and lymphoma: We assayed the cell cycle phase occupancy of both lymphoma cell lines and the murine primary B lymphocytes and observed no consistent changes between cell cycle profiles upon PRPS1 KO or PRPS2 KO (Fig. 4G, Supplementary Fig. 4B), demonstrating that the loss of either PRPS isoform does not interfere with Myc-dependent cell cycle progression.