Of all the compounds tested in the CA46 lymphoma cell line, we found 7 that yielded both statistically significant and opposing sensitivities between PRPS1 KO and PRPS2 KO cells compared to WT cells, 5 of which recapitulated their behavior in DG-75 cells: dithiothreitol (DTT), N-acetyl-l-cysteine (NAC), G6PDi-1, carmustine and auranofin. This evidence concerns the gene PRPS1 and lymphoma.