Interestingly, a significant number of T cell clones isolated from patients released IL-22, which modulates macrophage M2 polarization, collagen production and proliferation of hepatic stellate cells.The ability of parasite, like schistosomiasis, to orchestrate the immune system of their host is crucial for their survival, enabling them to evade excessive immune reactions [32]. The gene discussed is IL22; the disease is schistosomiasis.