Indeed, Th2 cytokines, particularly IL-13, are primarily responsible for the fibrotic process following the deposition of schistosome eggs in the liver, being this fibrotic process detrimental to the host, leading to hepatic and periportal fibrosis, which can obstruct blood flow and result in portal hypertension and potentially fatal esophageal bleeding [39]. This evidence concerns the gene IL13 and liver disorder.