Given the established roles of the CP, LS, and MS in modulating cognitive functions and brain states, including decision-making, learning, memory, and arousal (1, 5, 62, 63, 70–73), their preferential inhibition of BFCN→ACA neurons may facilitate brain-state–related cholinergic modulation of cognition. The gene discussed is CP; the disease is myeloid sarcoma.