GLP1R and Hepatic steatosis: To confirm that hepatic steatosis in IntL-Piezo1−/− mice is caused by the shortage of GLP-1, we administered exendin-4 (EX-4) intraperitoneally for 7 consecutive days in Piezo1fl/fl and IntL-Piezo1−/− mice after 10 weeks of HFD feeding.