TYK2 and tuberculosis: By contrast, patients with autosomal recessive (AR) complete IL-12Rβ1 (21–25) or TYK2 deficiency (26, 27) occasionally present TB following infection with M.tb, which is ~1,000 times more virulent than BCG and EM, during childhood or adolescence, rather than displaying MSMD during the first few years of life.