The findings indicated that the drug-like compounds identified in Solanecio mannii aqueous roots extract targeted 493 genes/proteins associated with cervical cancer, including NFKB1, STAT3, HIF1A, ESR1, PIK3CA, PPARG, HSP90AA1, and HSP90AB1, which were among the top 30 core targets. This evidence concerns the gene STAT3 and cervical cancer.