An increased level of expression of HIF1A is associated with tumour’s adaptation to low oxygen levels and hypoxia, promoting the Warburg effect by upregulating glycolytic enzymes and glucose transporters (Lactate Dehydrogenase A/LDHA and GLUT1), and increasing migration and angiogenesis potential of cancer cells (through the upregulation and production of VEGF and matrix metalloproteinases) [26–28]. Here, HIF1A is linked to cancer.