ADAM33 and sarcoma: The ECM component-related genes mutated in the sarcoma group were ADAMTS12, ADAM33, TSPAN5, AB3IBP, and EXT2. The ADAMTS12 protein is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, and all members of this gene family function as metalloproteinases that contribute to the formation, homeostasis, and remodeling of the ECM [69,70].