Regarding inflammatory markers circulating in serum we tested for markers engaged in innate (CxCL1/KC/GRO-α, CxCL2/MIP-2, CCL5/RANTES, TNF-α, IL-1β) and adaptive Th1, Th2 and Th17 responses (IFN-γ, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17, IL-23) and found that only CCL5/RANTES was increased in C3H/HeJ at day 15 post infection (Fig 5). This evidence concerns the gene CALCA and infection.