ABCB5 and cancer: According to Fig 7C, the most highly enriched KEGG pathways including “PI3K-Akt signaling pathway”, “MAPK signaling pathway”, “Proteoglycans in cancer”, “Rap1 signaling pathway”, “FoxO signaling Pathway” and “ERBB signaling pathway” could potentially contribute to regulating the impacts of ABCA10 and ABCB5 in tumor development.