Of them, the most common cancer driver gene across cancer types was B3GNTL1 (16/24 test cancer types), DNAm alteration of which has been recently discovered through bisulfite sequencing as a component of a non-invasive biomarker for early detection of cancer.56 This suggested the possible biological relevance of these pangenome-unique unambiguous probes in understanding cancer biology. This evidence concerns the gene QTGAL and cancer.