Biodistribution of [68Ga]Ga-Ec1-DOTA, [68Ga]Ga-Ec1-NOTA and [68Ga]Ga-Ec1-NODAGA in BALB/c nu/nu mice bearing human cancer xenografts demonstrated that the uptake of all 68Ga-labelled conjugates was significantly (p < 0.05) higher in EpCAM-positive SKOV-3 xenografts than in EpCAM-negative Ramos xenografts 3 h after injection (Fig. 6), demonstrating in vivo EpCAM-specific accumulation in tumors. Here, EPCAM is linked to cancer.