DARPins binding to tumor-associated molecular targets such as human epidermal growth factor receptor 2 (HER2), epithelial cell adhesion molecule (EpCAM), epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) have been described (Binz et al. 2017; Stefan et al. 2011; Zahnd et al. 2006; Steiner et al. 2008). Here, ERBB2 is linked to neoplasm.