To assess the neuroprotective effects of Hesperidin and DRB in the in vitro AD model induced by Aβ1–42, we measured the mRNA expression levels of ADAM10 (α-secretase) and BACE1 (β-secretase) genes using RT-qPCR, as well as the Aβ1–42 and phospho-Tau (T181) protein levels using ELISA. This evidence concerns the gene MAPT and Alzheimer disease.