SYNGAP1 and uveitis: Thus, we performed WES; however, the analysis did not identify any causal variants for uveitis, but it did pinpoint a causal variant for their intellectual impairment by identification of a novel, heterozygous likely pathogenic duplication in SYNGAP1 gene (OMIM # 603384 ) which encodes a ras GTPase-activating protein which is essential for cognition and synapse function [20].