CHMP5 and infection: The remaining one set of cultures exhibited highest, among all sets, mean level of infection at 2 h p.i., with the subsequent reduction of Spike level by 43% at 48 h p.i. Given that cultures were exposed to the virus only for 2 h of inoculation (after which the virus was washed out), the increase in the Spike transcript level supports the likelihood of virus replication in the cells within the cultures, with the rate of replication being higher in EUPL than in T21 cultures.