Although our experiments confirmed the importance of ACE2 and TMPRSS2 for the infection of cortical cells with a Spike-expressing virus, we cannot exclude the existence of additional alternative mediators/mechanisms facilitating the infection of cultures with SARS-CoV-2, especially given that the degree of reduction of the infection, particularly by the TMPRSS2 inhibitor camostat, varied between cultures. The gene discussed is ACE2; the disease is infection.