Given the differences in the age of SR-BI-/- mice in the published (>20 weeks [69]) and this study (6 weeks at infection), immunophenotyping of splenic B cells was performed in unmanipulated SR-BI-/- mice of the same age as those analyzed at 16 days post-MHV68 infection studies (8-9 weeks of age) using gating strategies outlined in Fig. S1. This evidence concerns the gene SCARB1 and infection.