SCARB1 and infection: Given that the germinal center B cells support the majority of the latent splenic MHV68 reservoir at 16 days post-infection, an increased MHV68-driven germinal center response (Fig. 3C and D) without a corresponding increase in the splenic latent reservoir of SR-BI-/- mice (Fig. 2A) suggested that the frequency of latently infected germinal center B cells was decreased in SR-BI-/- mice.