For instance, TLR5/Rag1 double knockout (DKO) mice demonstrate severe immune dysregulation compared to their TLR5 knockout (T5-KO) and Rag1 knockout (Rag1-KO) littermates, with frequent lethal infections caused by Pasteurellaceae and increased abscess formation in multiple organs [75]. The gene discussed is TLR5; the disease is infection.