LEP and depressive disorder: 2016). The hormone leptin has also been shown to influence stress responses by regulating stress‐related feeding behaviors (Pinto et al. 2004). The study examined the antidepressant‐like effects of the leptin hormone in an animal model of chronic stress. The hippocampus, a brain region that transduces leptin's antidepressant activity, was found to be a new paradigm for treating depressive disorders (Lu et al. 2006).