IU1‐47[37] represents a similarly established and characterized inhibitor of USP14, whereas Spautin‐1 is a reported inhibitor of USP10 and USP13, which was investigated in the context of melanoma cell growth inhibition.[38] Furthermore, we analyzed the effect of p97 inhibition on the cellular ubiquitome using the highly potent p97 inhibitor NMS‐873.[39] As p97 and the proteasome frequently cooperate in the turnover of ubiquitinated substrates, we investigated NMS‐873 in the presence of CFZ. The gene discussed is USP10; the disease is melanoma.