Escin activates ALDH to inhibit smoking‐induced cell death, and alleviates non‐alcoholic fatty liver disease through activating antioxidants and autophagy via Keap1‐Nrf2.[40, 41] β‐escin has a repair effect on atrophic regenerated muscle, it reduces inflammatory infiltration and fibrosis, as well as increases the number of muscle fibers.[42] However, there is no evidence for the role of Escin in pulmonary fibrosis. This evidence concerns the gene KEAP1 and pulmonary fibrosis.