Several PSMD14 inhibitors have been applied in tumor research, yet the development of PSMD14 agonists remains elusive.[51] In this work, we combined virtual screening and functional experiments to identify the small‐molecule agonist Pantethine, a vitamin B5 precursor that targets PSMD14 to stabilize SLC7A11, and demonstrated its anti‐ferroptosis and anti‐osteoporosis properties. Here, PSMD14 is linked to osteoporosis.