Notably, the highly expressed genes in the terrestrial IMC (260) and KC (194) were enriched in gene ontology (GO) terms associated with carbon fixation pathways, like carbon fixation (GO:00 15977), and photosynthesis/light harvesting (GO:0 009765) enriched in both IMC and KC, as well as chloroplast (GO:0 009507) in only KC. This evidence concerns the gene CALCA and keratoconus.