Notably, unlike E6 repression alone, combined E6/E7 repression, which rapidly induces highly efficient cellular senescence in normoxic HPV‐positive cancer cells [6, 7, 15, 28], was linked to a strong reduction in the levels of proteins that promote cell cycle progression, including B‐MYB, Cyclin A, Cyclin B1, Cyclin B2, and CDC25C (Figure 1A, left panels for each cell line). This evidence concerns the gene CCNA2 and cancer.