CCNB2 and cancer: Notably, unlike E6 repression alone, combined E6/E7 repression, which rapidly induces highly efficient cellular senescence in normoxic HPV‐positive cancer cells [6, 7, 15, 28], was linked to a strong reduction in the levels of proteins that promote cell cycle progression, including B‐MYB, Cyclin A, Cyclin B1, Cyclin B2, and CDC25C (Figure 1A, left panels for each cell line).