Although MFN2 knockout in mice is embryonic lethal, mutations in MFN2 are associated with multiple disorders, including Charcot–Marie–Tooth disease type 2A (CMT2A), a peripheral neuropathy disease (Cartoni et al., 2010; Chen et al., 2003; Sandoval et al., 2014), along with atherosclerosis and hypertension (Chen et al., 2004; Guo et al., 2007; Shen et al., 2007), exemplifying the importance of MFN2 for cellular homeostasis. This evidence concerns the gene MFN2 and atherosclerosis.