We found that estrogen (E2), luteinizing hormone (LH), and testosterone (T) levels were significantly higher in FKI mice compared to WT mice (Figs. 2A–2C), which is consistent with other OHSS models (Castillo et al., 2020; Kasum, 2010; van de Lagemaat et al., 2011). Here, PLOD1 is linked to ovarian hyperstimulation syndrome.