Additionally, in GC, NSUN2 is considered an oncogene, exhibiting significantly elevated expression levels in GC tissues and cells, where it suppresses apoptosis and promotes proliferation through m5C-dependent inhibition of p57Kip2 [13], or activates key genes like ORAI2 to facilitate peritoneal metastasis and colonization [14]. Here, ORAI2 is linked to gastric cancer.