HMOX1 and gout: By constructing murine models of gouty arthritis and observing joint swelling, synovial tissue edema, and inflammatory cell infiltration in mice, Cheng found that PAL attenuated MSU-induced gouty arthritis inflammation, indicating that Sirt1 alleviates M1 macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.