Gout initially manifests as acute inflammatory arthritis, the activation of the NLRP3 inflammasome triggered by uric acid is considered a key pathogenic mechanism in the acute inflammatory response of gout, which leads to the production of proinflammatory cytokines, including interleukin-1β (IL-1β) and IL-18 (30, 31). This evidence concerns the gene NLRP3 and gout.