Inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ), as well as pancreatic autoantibodies such as ICA, IAA, and ZnT8, are classic markers of T1D but lack specificity. The gene discussed is TNF; the disease is type 1 diabetes mellitus.