(68) identified 10 DISH-related loci through genetic association analysis, including multiple genes related to bone remodeling, such as osteogenesis master regulator RUNX2, BMP signaling pathway (CHRDL2, NOG, GDFS), wnt signaling pathway (ROR2) and ILI1 etc., implying that overactive osteogenesis plays an important role in the disease development of DISH. The gene discussed is CHRDL2; the disease is diffuse idiopathic skeletal hyperostosis.