IGHA1 and ocular melanoma: Virulence/persistence: Critical for bacterial virulence and persistence in a mammalian model of OM (Harrison et al., 2013); upregulates IgA1 protease which mediates antibiotic resistance, optimal invasion and long-term intracellular survival in human respiratory epithelial cells (Clementi et al., 2014)Colonisation: Additional regulatory management of molecules shown to mediate attachment (Harrison et al., 2013)